We implement optical technologies such as diffuse optical spectroscopies (functional near infrared spectroscopy, diffuse correlation spectroscopy) and imaging modalities for studying the brain function to improve human performance and for characterization of brain related diseases such as autism and stroke.
Cognitive Function Imaging
Utilizing Functional near-
Optical Imaging for Diagnosis of Autism Spectrum Disorder
Compared with TD children, children with ASD showed weaker bilateral resting-
Fig (Above): Schematic representation of the brain showing the location of each measurement channel.
Fig (Above): Correlation maps of HbO2 and Hb for TD and ASD children. Three seeds locating at the left superior (Ch4), middle (Ch6) and inferior (Ch8) gyrus were selected for generating correlation maps. The seed region can be visually recognized by the maximal color value in each map. The mapping area in each hemisphere was about 6 cm×6 cm.
Jun Li**, Lina Qiu, Lingyu Xu, Ernest V. Pedapati, Craig A. Erickson and Ulas Sunar. Characterization of autism spectrum disorder with spontaneous hemodynamic activity. Biomed. Opt. Express 7, 3871-
Resting State Functional Connectivity with DCS
Fig (Above): (a) Locations of sources (red) and detectors (blue) in reference to the international EEG 10-
20 system. The source- detector distance was 2.75 cm for S- DDLFC,1, S- DDLFC,2, S- DIFC and 1.0 cm for S- Ds. (b) An example of the placement of the probe on the subject. (c) The placement of each optode on the probe in (b).
Fig (Left): (a) Group average for inter-
regional (0.32±0.32), (0.34±0.27) and intra- regional RSFC (0.64±0.25) on the left cortex. (b) Inter- regional (0.34±0.29), (0.34±0.26) and intra- regional RSFC (0.62±0.23) on the right cortex. The error bar is the standard deviation across all subjects. The z- test shows the difference between the intra- and inter- regional RSFC on both cortex is significant with P?0.0002, while there was no significant difference between the left and right cortex (z- test: P>0.8)
Li J, Poon C-